Method for determining the pH in the mucosa of the stomach or the gastrointestinal tract
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United States of America Patent
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Sep 26, 2000
Issued Date -
N/A
app pub date -
Jan 5, 1999
filing date -
Jul 8, 1996
priority date (Note) -
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Abstract
The carbon dioxide tension in the wall of the stomach or gastrointestinal tract is determined by inserting into the stomach a semipermeable balloon filled with a saline solution. The result obtained from analyzing the carbon dioxide fraction in the saline solution is multiplied by a correction factor to obtain a stabilized measured value for the carbon dioxide fraction relating to the blood flowing through the wall of the stomach or the gastrointestinal tract, which stabilized measured value corresponds to a measured carbon dioxide fraction pertaining to a retention time of an hour or more, and multiplying the carbon dioxide tension PaCO.sub.2 in the arterial blood with a first factor F.sub.1 to obtain a first correction product, and multiplying the stabilized value of the carbon dioxide tension PiCO.sub.2 in the blood flowing through the wall of the stomach or the gastrointestinal tract by a second factor F.sub.2 to obtain a second correction product, and adding the first correction product to a basic factor F.sub.0 and subtracting the second product therefrom in accordance with the formula: pHi=F.sub.0 +F.sub.1 *PaCO.sub.2 -F.sub.2 * PiCO.sub.2 in which pHi forms a measure for the pH of the stomach or the gastrointestinal tract.
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