Process for preparing (s)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide
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United States of America Patent
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Sep 26, 2000
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May 7, 1999
filing date -
May 8, 1998
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Abstract
The present invention relates to a process for preparing (S)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of .alpha.-ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase. This process makes it possible to achieve good production efficiency on the industrial scale.
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