Process for the preparation of thiazole derivatives
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United States of America Patent
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Sep 19, 2000
Grant Date -
N/A
app pub date -
Aug 13, 1999
filing date -
Dec 19, 1996
priority date (Note) -
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Abstract
The invention relates to a process for the preparation of a compound of the formula ##STR1## and, where applicable, its E/Z-isomers, mixtures of E/Z-isomers and/or tautomers, in each case in free form or in salt form, wherein Q is CH or N, Y is NO.sub.2 or CN, Z is CHR.sub.3, O, NR.sub.3 or S, R.sub.1 and R.sub.2 are either each independently of the other hydrogen or unsubstituted or R.sub.4 -substituted C.sub.1 -C.sub.8 alkyl, or together form an alkylene bridge having two or three carbon atoms, and said alkylene bridge may additionally contain a hetero atom selected from the group consisting of NR.sub.5, O and S, R.sub.3 is H or unsubstituted or R.sub.4 -substituted C.sub.1 -C.sub.12 alkyl, R.sub.4 is unsubstituted or substituted aryl or heteroaryl, and R.sub.5 is H or C.sub.1 -C.sub.12 alkyl; which comprises a) reacting a compound of the formula ##STR2## and, where applicable, its E/Z-isomers, mixtures of E/Z-isomers and/or tautomers, in each case in free form or in salt form, which is known or can be prepared by processes known.
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