Nematode-extracted serine protease inhibitors and anticoagulant proteins
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United States of America Patent
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Sep 19, 2000
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N/A
app pub date -
Feb 12, 1999
filing date -
Oct 18, 1994
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Expired
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Abstract
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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