Prolonged release active agent dosage form adapted for gastric retention
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United States of America Patent
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Sep 19, 2000
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N/A
app pub date -
Aug 10, 1998
filing date -
Aug 11, 1997
priority date (Note) -
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Abstract
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
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