Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
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United States of America Patent
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Sep 19, 2000
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app pub date -
Mar 29, 1999
filing date -
Sep 25, 1997
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Abstract
A liposome formulation containing a Vinca Alkaloid and an anion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholesterol and disteraroylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.
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