Pyrrolnitrin biosynthesis genes and uses thereof

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United States of America Patent

PATENT NO 6117670
SERIAL NO

09028934

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Abstract

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The present invention is directed to the production of pyrrolnitrin in a host via recombinant expression of the polypeptides needed to biologically synthesize pyrrolnitrin. Genes isolated from P. fluorescens, P. pyrrocinia, B. cepacia, and M. fulvus that encode polypeptides necessary to produce pyrrolnitrin are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize pyrrolnitrin from any organism capable of producing pyrrolnitrin. The isolated genes may be transformed and expressed in a desired host organisms to produce pyrrolnitrin according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of pyrrolnitrin.

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Patent Owner(s)

Patent OwnerAddress
SYNGENTA INVESTMENT CORPORATION2200 CONCORD PIKE WILMINGTON DE 19803

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hammer, Philip Eugene Cary, NC 2 24
Hill, Dwight Steven Cary, NC 14 273
Kirner, Sabine Puchheim, DE 2 42
Lam, Stephen Ting Raleigh, NC 9 202
Ligon, James Madison Apex, NC 11 152
van, Pee Karl-Heinz Bannewitz, DE 3 42
Young, Thomas R Vero Beach, FL 14 189

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