Cyanine dyes and synthesis methods thereof

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United States of America Patent

PATENT NO 6114350
SERIAL NO

09294678

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Abstract

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A cyanine dye having the formula ##STR1## wherein R.sub.1 -R.sub.8 are each independently selected from a group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl group, and C.sub.0 -C.sub.4 alkyl group having a hydrophilic substituent thereon. R.sub.11 and R.sub.12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

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Patent Owner(s)

Patent OwnerAddress
NEN LIFE SCIENCE PRODUCTS INC548 ALBANY STREET BOSTON MA 02118

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ahern, David George Lexington, MA 5 263
Bobrow, Mark Norman Lexington, MA 19 476
Buzby, Philip Richard Brockton, MA 18 1508
Erickson, Thomas Joseph Carlisle, MA 7 302
Miller, Jr Joseph John Dracut, MA 5 263
Randall, Malcolm Harry Wayland, MA 5 263
Trometer, Joseph David Framingham, MA 5 263

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