Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
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United States of America Patent
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Sep 5, 2000
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app pub date -
May 8, 1997
filing date -
May 8, 1997
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Abstract
Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
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