Peptides and methods against diabetes
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United States of America Patent
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Sep 5, 2000
Issued Date -
N/A
app pub date -
Feb 14, 1994
filing date -
Mar 21, 1989
priority date (Note) -
Expired
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Abstract
This invention relates to methods of preventing or reducing the severity of diabetes. In one embodiment, the method involves administering to the individual a peptide having substantially the sequence of a on-conserved region sequence of a T cell receptor present on the surface of T cells mediating diabetes or a fragment thereof, wherein the peptide or fragment is capable of causing an effect on the immune system to regulate the T cells. In particular, the T cell receptor has the V.beta. regional V.beta.6 or V.beta.14. In another embodiment, the method involves gene therapy. The invention also relates to methods of diagnosing diabetes by determining the presence of diabetes predominant T cell receptors.
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