Peptidic molecules which have been isotopically substituted with .sup.13 C, .sup.15 N and .sup.2 H in the backbone but not in the sidechains
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United States of America Patent
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Aug 29, 2000
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N/A
app pub date -
Sep 2, 1997
filing date -
Sep 2, 1997
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Abstract
Peptidic molecules suitable for three dimensional NMR structure determination are provided which have been substituted with .sup.13 C and/or .sup.15 N in the backbone and/or at the .alpha.-carbon with .sup.2 H but not otherwise in the sidechains of the amino acid residues. One or more amino acids, amino acid species or substantially all of the amino acid residues of the molecule may be so substituted. A method of making the substituted peptidic molecules substituted in this manner is provided.
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