Cyclic Antiplatelet peptides with pseudo-bond
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United States of America Patent
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Aug 22, 2000
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N/A
app pub date -
Apr 9, 1997
filing date -
Jun 4, 1992
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Expired
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Abstract
The present invention relates to cyclic peptide analogs containing a pseudo-bond, useful as platelet aggregation inhibitors. An example of a compound of this invention includes Cyclo[Ala.PSI.[CH.sub.2 NH]-Arg-Gly-Asp-.delta.-Glu](NHBn).cndot.CF.sub.3 CO.sub.2 H. These compounds inhibit the binding of fibrinogen to the platelet GPIIb-IIIa integrin receptor which inhibits platelet aggregation and therefore these compounds act as potent antithrombotics.
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