N-3 substituted pyrimidin-4-ones with AII antagonistic activity
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United States of America Patent
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Aug 1, 2000
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N/A
app pub date -
Oct 16, 1998
filing date -
Apr 19, 1996
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Expired
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Abstract
N-3-substituted pyrimindin-4-ones with angiotension II (AII) antagonistic activity are characterized by the presence of a heterocyclic moiety bound to the 3-position of the pyrimidinone ring and a biphenylmethyl moiety bound to the 5-position of the pyrimidinone ring. Preferred heterocyclic moieties include furan, thiophene, thiazole, isothiazole, oxazole, isoxazole, pyridine, pyrimidine, pyrazine, and pyridazine rings.
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