Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds
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United States of America Patent
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Jul 25, 2000
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Sep 23, 1998
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Sep 26, 1997
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Abstract
The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with azabenzimidazole-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to azabenzimidazole compounds and pharmaceutical compositions comprising these compounds.
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