Immortalized retinal cell lines and their applications
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United States of America Patent
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Jul 18, 2000
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app pub date -
Oct 30, 1998
filing date -
Apr 19, 1996
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Abstract
Immortalized cell lines of retinal origin (retinal endothelial and retinal pigmentary epithelial origin) which are capable of being implanted in the retina and of conveying a substance of therapeutic interest into the eye and the central nervous system. Such lines can also serve as a model for studying the blood/central nervous system interfaces. These lines are derived from primary cultures of retinal cells selected from the group comprising the primary retinal endothelial cells and the primary retinal epithelial cells, comprise a nucleic acid fragment containing at least one immortalizing fragment of a heat-sensitive viral oncogene, which nucleic acid fragment may be associated with at least one selection gene, and exhibit the morphological characteristics and at least the surface antigen expression characteristics of the corresponding primary culture cells.
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