Methods of treating or preventing thromboses

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United States of America Patent

PATENT NO 6087375
SERIAL NO

09330744

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have thrombin inhibition activity are provided. Specifically, the thrombin inhibitor compounds of the present invention are derivatives of the known thrombin inhibitor argatroban, which can be covalently linked to chemically reactive functionalities on various blood components. The conjugated thrombin inhibitors thereby have extended lifetimes in the bloodstream, as compared to the unconjugated parent drug, and are, therefore, capable of maintaining thrombin inhibitory activity for extended periods of time as compared to the unconjugated parent drug. Also provided herein are methods for inhibiting thrombin activity in vivo comprising administering to the bloodstream of a mammalian host the novel compounds of the present invention.

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Patent Owner(s)

Patent OwnerAddress
CONJUCHEM LLC10182 CULVER BOULEVARD CULVER CITY CA 90232

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bridon, Dominique P Outremont, CA 63 1828
Ezrin, Alan Moraga, CA 1 19
Milner, Peter Los Altos Hills, CA 20 33

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