Haemoglobin-hydroxyethyl starch conjugates as oxygen carriers
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United States of America Patent
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Jul 4, 2000
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N/A
app pub date -
Jan 6, 1999
filing date -
Jul 8, 1996
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Expired
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Abstract
The present invention relates to new oxygen transfer agents which comprise haemoglobin-hydroxyethylstarch conjugates, and processes for their preparation. The invention furthermore relates to the use of the oxygen transfer agents as a blood substitute, plasma expander, perfusion agent, haemodilution agent and/or cardioplegic solution. The invention relates in particular to oxygen transfer agents which comprise a haemoglobin-hydroxyethylstarch conjugate in which the haemoglobin and the hydroxyethylstarch are linked to one another selectively via amide bonds between free amino groups of the haemoglobin and the reducing end group of the hydroxyethylstarch, which is present in oxidized form.
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