Conformationally locked nucleosides and oligonucleotides
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Jul 4, 2000
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N/A
app pub date -
May 11, 1999
filing date -
May 11, 1999
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Abstract
Conformationally restricted 3',5'-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C3' and C5' of nucleosides through a linker or linking molecule. The nucleoside bases may be modified or unmodified. The nucleosides can be used as oligonucleotide building blocks or as small molecule pharmaceutical ingredients.
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