Oligonucleotide treatments and compositions for human melanoma
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United States of America Patent
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Jun 27, 2000
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N/A
app pub date -
Mar 25, 1997
filing date -
Mar 26, 1996
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Abstract
The invention generally provides for compositions and methods of inhibiting the proliferation of human melanoma cancer cells. By administering a therapeutically effective amount of a c-myc oligonucleotide to a human melanoma cancer cell, melanoma cancer cell proliferation can be arrested or inhibited, metastases reduced from a tumor, and apoptosis induced in melanoma cancer cells. Oligonucleotides that are complementary to c-myc polynucleotides are referred to herein as 'c-myc oligonucleotides.' A particularly efficacious embodiment of the invention relates to compositions and methods concerning the co-administration of c-myc oligonucleotides and cisplatin.
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