Materials and methods relating to the regulation of polypeptide production in cells
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United States of America Patent
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Jun 13, 2000
Grant Date -
N/A
app pub date -
Mar 4, 1998
filing date -
Feb 14, 1995
priority date (Note) -
Expired
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Abstract
This application relates to cell lines transfected with (a) nucleic acid encoding one or more hormone receptors, the receptors being capable of transmitting a signal, and (b) nucleic acid encoding a desired polypeptide, the nucleic acid encoding the polypeptide being under the control of a promoter containing regulatory elements responsive to the signal transmitted by the receptor(s) so that transcription of the nucleic acid encoding the desired polypeptide is modulated by the level of the hormone(s) in the patient. Preferably, the receptors are the GIP or GLP-1 receptors controlling the production of insulin in the cells in response to changes in the metabolic status of a patient. The application also relates to compositions comprising these cells and their use in methods of medical treatment.
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