1H-4(5)-cyclo-substituted imidazole derivatives as histamine H.sub.3 receptor agents
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United States of America Patent
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Jun 6, 2000
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N/A
app pub date -
Feb 11, 1998
filing date -
Jun 6, 1996
priority date (Note) -
Expired
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Abstract
The present invention is directed to 1H-4(5)-substituted imidazole derivates of formula (I), wherein A is (a); (b); or (c) ##STR1## wherein R.sub.1 is lower alkyl or lower alkoxy; R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7 and R.sub.8 are each independently hydrogen or lower alkyl; R.sub.6 is hydrogen, lower alkyl or lower alkoxy and R.sub.5 and R.sub.6 can be joined to form a 4, 5 or 6 membered ring. The compounds of formula (I) have H.sub.3 histamine receptor agonist activity. The pharmaceutically acceptable salts, and individual stereoisomers of compounds of formula (I) above, as well as mixtures thereof, are also contemplated as falling within the scope of the present invention. The present invention also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with an effective amount of a compound of formula (1). The present invention also provides a method of treating conditions in which activation of histamine H.sub.3 receptors may be of therapeutic importance such as allergy, inflammation, cardio or cerebrovascular disease, gastrointestinal disorders and CNS disorders involving psychiatric disorders.
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