Nucleoside derivatives and process for preparing the same
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United States of America Patent
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Jun 6, 2000
Grant Date -
N/A
app pub date -
May 1, 1998
filing date -
Nov 2, 1995
priority date (Note) -
Expired
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Abstract
According to the present invention, provided are novel nucleoside derivatives having antiviral activity, in particular, anti-HBV (anti-Hepatitis-B Virus) activity, represented by general formula (I), wherein R.sub.1 represents hydrogen, phosphate, phosphonate, alkyl or acyl; R.sub.2 represents alkoxy or halogen; R.sub.3 represents substituted or non-substituted pyrimidine or purine base; and X represents O, S, SO or SO.sub.2 ; pharmaceutically acceptable salts thereof, and processes thereof. As the compound (I) has two or more asymmetric carbon atoms, all possible stereoisomers and mixtures thereof are included in the scope of the present invention. ##STR1##
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