Process for the preparation of nizatidine
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United States of America Patent
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May 30, 2000
Grant Date -
N/A
app pub date -
Mar 10, 1999
filing date -
Sep 11, 1996
priority date (Note) -
Expired
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Abstract
The present invention relates to a novel process for the preparation of nizatidine, N-[2-[[[2-(dimethylamino)methyl-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, and pharmaceutically acceptable salts thereof, comprising reacting a compound of formula II ##STR1## with a compound of formula III ##STR2## or a salt thereof, in which X represents a leaving group, in the presence of methylamine in the presence of an inert diluent.
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