Process for the diagnostic assessment and monitoring, as well as medicaments for the therapy of states of shock in humans

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United States of America Patent

PATENT NO 6066465
SERIAL NO

08817096

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Abstract

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A method is provided for detecting shock by measuring the concentration of cyclophilins in a patient's blood and comparing the measured concentration against a control. The severity of shock is then evaluated, an increase in cyclophilin concentrations over control levels being associated with severity. Measuring methods include enzymological techniques, such as rotomase activity assay; immunological procedures, such as radioimmunoassay and ELISA; peptide chemical processes, such as affinity chromatography; and radiochemical approaches, such as contacting the sample with radioactive cyclosporin.

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Patent Owner(s)

Patent OwnerAddress
PAZ ARZNEIMITTEL-ENTWICKLUNGSGESELLSCHAFT MBHIN DER SCHILDWACHT 13 D-6230 FRANKFURT 80

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bang, Holger Erlangen, DE 5 26
Brune, Kay Marloffstein, DE 25 267
Tiegs, Gesa Constance, DE 2 2
Wendel, Albrecht Tuebingen, DE 8 41

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