Cephalosporin synthesis
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United States of America Patent
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May 16, 2000
Issued Date -
N/A
app pub date -
Sep 30, 1998
filing date -
Apr 25, 1994
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Expired
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Abstract
A process for the production of a compound of formula ##STR1## wherein R.sup.a denotes hydrogen or silyl; R.sup.b denotes a group of formula --OR.sup.e, wherein R.sup.e denotes hydrogen or alkyl; and R.sup.c and R.sup.d together denote a bond; in free form or in salt form, which process comprises the step of spitting, in the presence of ozone, the double bond in position 3 of the ring structure of a compound of formula III ##STR2## wherein R.sub.2 and R.sub.3 are the same or different and independently of each other denote hydrogen or an organic group, and X.sup.- denotes the anion of an inorganic or organic acid and optionally silylating the amine group in position 7 of the ring system.
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