N-benzenesulfonyl-L-proline derivatives, method for preparing and therapeutic use
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United States of America Patent
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May 16, 2000
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N/A
app pub date -
May 6, 1999
filing date -
Dec 4, 1996
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Abstract
The present invention relates to compounds selected from the group consisting of (i) the compounds of formula I: ##STR1## in which: X is a halogen atom or a methyl group, A is a group --N(R.sub.3)CO-- or --CO--N(R.sub.3)--, B is a single bond, --CH.sub.2 -- or --CH.sub.2 --O--, R.sub.1 is H, a C.sub.1 -C.sub.3 alkyl group or a CF.sub.3 group, R.sub.2 and R.sub.3 are each independently H or a C.sub.1 -C.sub.3 alkyl group, W is CH or N, and n is 2, 3, 4 or 5; and (ii) their addition salts. It further relates to the process for their preparation and to their use in therapeutics, especially for combating pathological conditions involving bradykinin.
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