Fluorescent peptides
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United States of America Patent
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Apr 25, 2000
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app pub date -
Jul 10, 1996
filing date -
Apr 4, 1995
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Abstract
The invention provides biologically active compounds of the formula: ##STR1## where R.sub.1 is a light-emitting moiety and R.sub.7 is a peptide of between 2 and 200 amino acids. X is selected from the group including .dbd.O, .dbd.S, --OH, .dbd.C.tbd.O, .dbd.NH, --H, --OR, --NR, --R, --R.sub.3 R.sub.4, wherein each R, R.sub.4 and R.sub.3, independently, is H or a C1-C6 branched or unbranched, substituted or unsubstituted, alkyl. The compounds are both biologically active and optically detectable. The peptide is chemically attached to the light-emitting moiety at an amino acid position which is not involved in binding to the peptide's receptor. In this way, the peptide's affinity for its receptor is not significantly decreased, and the compound retains high biological activity and can be easily detected using standard optical means.
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