Process for the chemical synthesis of oligonucleotides
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United States of America Patent
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Apr 11, 2000
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N/A
app pub date -
Feb 13, 1997
filing date -
Sep 12, 1991
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Expired
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Abstract
A process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.
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