Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
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United States of America Patent
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Apr 4, 2000
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app pub date -
Jul 31, 1996
filing date -
Aug 6, 1991
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Abstract
##STR1## Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.
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