Materials and methods relating to the identification and sequencing of the BRCA2 cancer susceptibility gene and uses thereof
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United States of America Patent
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Apr 4, 2000
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N/A
app pub date -
Nov 25, 1996
filing date -
Nov 23, 1995
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Expired
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Abstract
The identification and sequencing of the BRCA2 gene is disclosed as well as the amino acid sequence of the corresponding BRCA2 polypeptides. BRCA2 alleles including those with mutations in the BRCA2 gene which are associated with a predisposition to develop cancer, especially breast and ovarian cancer are also disclosed. The present invention further relates to polypeptides encoded by the above nucleic acid. The present invention further relates to uses of much BRCA2 nucleic acid and BRCA2 polypeptides, in particular in the diagnostic, prognostic or therapeutic treatment of cancer.
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