Passivated porous polymer supports and methods for the preparation and use of same
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United States of America Patent
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Apr 4, 2000
Issued Date -
N/A
app pub date -
Nov 30, 1998
filing date -
Jun 19, 1992
priority date (Note) -
Expired
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Abstract
This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.
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