Importance

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Abstract

A thiazole compound represented by general formula (I), wherein R is hydrogen atom, a hydroxy group, a straight or branched C.sub.1 -C.sub.6 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, phenyl group, a phenyl group having one to three substituents selected from a group consisting of a C.sub.1 -C.sub.4 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, fluorine, chlorine, bromine and an amino group, a C.sub.1 -C.sub.5 alkylphenyl group, a phenyl group having one to three substituents selected from a group consisting of a C.sub.1 -C.sub.4 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, fluorine, chlorine, bromine and an amino group, a substituted or unsubstituted guanidino group, or an amino group having a general formula: NR.sub.3 R.sub.4 in which R.sub.3 and R.sub.4, identical to or different from each other, represent independently a hydrogen atom, a C.sub.1 -C.sub.6 lower alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, a substituted or unsubstituted pyridyl group, a phenyl group having one to three substituents selected from a group consisting of a C.sub.1 -C.sub.4 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, a halogen atom, an amino group, a cyano group and a nitro group, a piperidine group or C.sub.1 -C.sub.4 alkylpiperidine group; R.sub.1 and R.sub.2, identical to or different from each other, are independently a hydrogen atom, a hydroxy group, a C.sub.1 -C.sub.6 lower alkyl group, phenyl group, a phenyl group having one substituent selected from a group consisting of a C.sub.1 -C.sub.4 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, a halogen atom, a nitro and a cyano group, a C.sub.1 -C.sub.5 alkylphenyl group, or a pyridine group; R.sub.5, R.sub.6, R.sub.7 and R.sub.8, identical to or different from each other, are independently a hydrogen atom, a hydroxy group, a C.sub.1 -C.sub.4 lower alkyl group, a C.sub.1 -C.sub.4 lower alkoxy group, phenyl group, or a phenyl group substituted with a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group or a halogen atom, or a C.sub.1 -C.sub.3 alkylphenyl group; Het is a 3-, 4- or 5-membered unsaturated monocyclic group, or 6-to 12-membered unsaturated fused cyclic group, said monocyclic and fused cyclic group being comprised of one or more hetero atoms selected from oxygen, oxidative nitrogen and oxidative sulfur atom are disclosed. These compounds show excellent anti-ulcer activity. ##STR1##

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