Anti-idiotypic antibody induction of anti-tumor response
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United States of America Patent
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Mar 28, 2000
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Jul 21, 1994
filing date -
Oct 17, 1988
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Abstract
Novel compositions and methods are described for stimulating a patient's immune system to tumor cells which bear a gp72 tumor-associated antigen and thereby eliciting a tumoricidal effect. Anti-idiotypic human monoclonal antibodies and idiotopic regions thereof to primary antibodies which bind selectively to an antigenic determinant of gp72 are provided to mediate the humoral and cellular components of the patient's immune system. The immunogenic agents find use both in vivo and in vitro.
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