DNA encoding glucuronyltransferase
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United States of America Patent
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Mar 21, 2000
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Apr 14, 1998
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May 16, 1997
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Abstract
A DNA having a base sequence encoding a polypeptide of a glucuronyltransferase characterized in that: A) action: said glucuronyltransferase transfers glucuronic acid from a glucuronic acid donor to a glucuronic acid acceptor; B) substrate specificity: said glucuronyltransferase selectively transfers glucuronic acid to N-acetyllactosamine residue of asialoorosomucoid and neural cell adhesion molecule; C) optimum reaction pH: said glucuronyltransferase has an optimum pH of about 6.0 to 6.5 (in 100 mM, MES buffer at 37.degree. C.); D) inhibition and activation: said glucuronyltransferase is activated by Mn.sup.2+ and the activity is maintained in the presence of 5 mM of neolactotetraose-phenyl-C.sub.14 H.sub.29 ; and E) molecular weight: said glucuronyltransferase has a molecular weight of about 45,000 dalton measured by reductive SDS-polyacrylamide gel electrophoresis and a molecular weight of about 90,000 dalton measured by gel filtration.
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