Transgenic mouse expressing an .beta.-Amyloid transgene

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United States of America Patent

PATENT NO 6037521
SERIAL NO

08339708

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Abstract

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The invention relates to an animal model of human Alzheimer's disease that is useful for determining the mechanism of the disease and for developing and testing potential therapeutic drugs. More particularly, the present invention relates to the creation of transgenic non-human mammalian animals having integrated into their genome an exogenous DNA construct that encodes a portion of a .beta.-amyloid precursor protein ('APP') and that is designed to overexpress in various types of animal tissues.

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Patent Owner(s)

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HOECHST JAPAN LIMITEDTOKYO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kawarabayashi, Takeshi Maebashi, JP 3 55
Kobayashi, Takashi Fukuoka, JP 692 7856
Sato, Masahiro Kawagoe, JP 437 2916
Shoji, Mikio Gunma-gun, JP 8 178
Tada, Norihiro Kawagoe, JP 2 40

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