Interaction of cyclin D1 and estrogen receptor and its use in assays
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United States of America Patent
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Mar 7, 2000
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N/A
app pub date -
Apr 6, 1999
filing date -
Apr 19, 1996
priority date (Note) -
Expired
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Abstract
The present invention relates to the finding that cyclin D1 interacts with estrogen receptor to provide activation of estrogen responsive genes. The present invention provides in vitro and in vivo assays to measure the interaction. The in vivo assays may be conducted in cells which grow in response to estrogen, particularly breast tumour cells.
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