Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
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United States of America Patent
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Feb 29, 2000
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N/A
app pub date -
Dec 29, 1995
filing date -
May 18, 1993
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Expired
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Abstract
The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.
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