Transgenic animals overexpressing MDM2
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United States of America Patent
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Feb 22, 2000
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app pub date -
Jun 25, 1998
filing date -
Jul 3, 1997
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Abstract
The present invention relates to transgenic, non-human animals overexpressing a MDM2 gene. These animals model MDM2 over-expression associated with human tumors, display a major phenotype characterized by the severe skin disorder ichthyosis, and are useful for identifying compounds for the treatment of human disease. Therefore, the invention also relates to methods of using the animals for identifying compounds effective for the treatment of diseases of the skin and respiratory tract, and to the compounds themselves.
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