Stereoselective process for enalapril

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United States of America Patent

PATENT NO 6025500
SERIAL NO

09397949

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Abstract

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The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, enalapril.

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Patent Owner(s)

Patent OwnerAddress
MERCK & CO INC126 EAST LINCOLN AVENUE P O BOX 2000 RAHWAY NEW JERSEY 07065-0900

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huffman, Mark A Edgewater, NJ 20 84
Leblond, Carl Somerset, NJ 8 6
Reider, Paul J Westfield, NJ 24 97
Sun, Yongkui Bridgewater, NJ 11 43

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