Nucleic acid polymer/intercalator monolayer and methods of using and making thereof
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United States of America Patent
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Feb 1, 2000
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N/A
app pub date -
Nov 7, 1997
filing date -
Mar 13, 1995
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Expired
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Abstract
The present invention has an object to provide an easy method for detecting a nucleic acid polymer in aqueous phase. The present invention provides a method for detecting the amount of nucleic acid polymer, which comprises the steps of modifying an intercalator to be amphiphilic by using a hydrophobic group, spreading the amphiphilic intercalator on an aqueous solution containing a nucleic acid polymer to form a monolayer of said nucleic acid polymer and said amphiphilic intercalator at the gas-water interface, and measuring surface pressures per unit area of said monolayer.
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