Kainate-binding, human CNS receptors of the EAA3 family

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United States of America Patent

PATENT NO 6018023
SERIAL NO

08487691

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Abstract

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Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

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Patent Owner(s)

Patent OwnerAddress
NPS PHARMACEUTICALS INC550 HILLS DRIVE THIRD FLOOR BEDMINSTER NJ 07921

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Elliott, Candace E Etobicoke, CA 20 14
Kamboj, Rajender Mississauga, CA 82 842
Nutt, Stephen L Etobicoke, CA 26 15

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