Mannich bases of conjugated styryl ketones

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United States of America Patent

PATENT NO 6017933
SERIAL NO

09238434

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Abstract

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Mannich bases of conjugated styryl ketones have been developed which are effective as cytotoxicity and anticancer agents, and which also have antifungal activity. Preferred compounds are those of the formula ##STR1## where R.sub.1 is Cl, CH.sub.3 or OCH.sub.3 and R.sub.2 is H or Cl. A compound of particular interest is (3-[3-(4-chlorophenyl)-2-propenoyl]-4-[2-(4-chlorophenyl)vinylene]-1-ethyl-4-piperidinol hydrochloride.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INCUNIVERSITY OF SASKATCHEWAN ROOM 304 KIRK HALL 117 SCIENCE PLACE SASKATOON SASKATCHEWAN S7N 5C8

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dimmock, Jonathan R Saskatoon, CA 4 2
Manavathu, Elias K Windsor, CA 1 1

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