Pyridonecarboxylic acid derivatives and intermediates for the synthesis thereof
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United States of America Patent
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Jan 25, 2000
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N/A
app pub date -
Aug 25, 1998
filing date -
Feb 27, 1996
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Expired
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Abstract
This invention relates to pyridonecarboxylic acid derivatives of the following general formula, esters thereof and salts thereof, as well as pharmaceutical preparations containing them. ##STR1## wherein: R is cycloalkyl which may be substituted by halogen, or the like; X is hydrogen, lower alkyl, amino or the like; Y is hydrogen or halogen; A is nitrogen or a group of the formula C--Z in which Z is lower alkoxy that may be substituted by halogen, or the like; R.sub.1 and R.sub.2 may be the same or different and are each hydrogen or the like; R.sub.3 is hydrogen or lower alkyl; R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 may be the same or different and are each hydrogen, halogen or lower alkyl; m is 0 or 1; and n and p may be the same or different and are each 0 or 1. This invention also relates to bicyclic amine compounds useful as direct intermediates for the synthesis of the above-described pyridonecarboxylic acid derivatives.
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