Method of using tetracycline compounds to enhance interleukin-10 production

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United States of America Patent

PATENT NO 6015804
SERIAL NO

09151534

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Abstract

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The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF .alpha. production.

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Patent Owner(s)

Patent OwnerAddress
NEW YORK RESEARCH FOUNDATION OF STATE UNIVERSITY OF THEPOST OFFICE BOX 9 ALBANY NY 12209

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Golub, Lorne M Smithtown, NY 53 1446
Greenwald, Robert A Melville, NY 10 428
Haas-Smith, Sally Penfield, NY 2 28
Lee, Hsi-Ming Setauket, NY 15 254
Moak, Susan A Bayside, NY 1 25
Ritchlin, Christopher T Canandaigua, NY 12 438

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