Serine protease inhibitors-cycloheptane derivatives
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United States of America Patent
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Jan 18, 2000
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N/A
app pub date -
Dec 4, 1997
filing date -
Nov 21, 1994
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Abstract
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compounds of the invention are useful in treating conditions such as adult respiratory distress syndrome, septic shock, and multiple organ failure.
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