Method of using vitamin D.sub.3 analogs with bis C-20 side chains
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United States of America Patent
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Dec 28, 1999
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N/A
app pub date -
Apr 16, 1998
filing date -
Apr 28, 1997
priority date (Note) -
Expired
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Abstract
This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin D.sub.3 analog of the Formula I wherein: X is H.sub.2 or CH.sub.2 ; Y is hydrogen, hydroxy or fluorine; Z is hydroxy; R.sub.1 and R.sub.2 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.1 and R.sub.2 together with C.sub.25 form a (C.sub.3 -C.sub.6) cycloalkyl or cyclofluoroalkyl; R.sub.3 and R.sub.4 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.3 and R.sub.4 together with C.sub.25' form a (C.sub.3 -C.sub.6)cycloalkyl or cyclofluoroalkyl; A is a single bond or a double bond; B.sub.1 is a single bond, an E-double bond, a Z-double bond or a triple bond; and B.sub.2 is a single bond, an E-double bond, a Z-double bond or a triple bond; or a prodrug thereof.
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