Glucosamine disaccharides, method for their preparation, pharmaceutical composition comprising same, and their use
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United States of America Patent
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Dec 21, 1999
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N/A
app pub date -
Sep 11, 1996
filing date -
Nov 17, 1993
priority date (Note) -
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Abstract
The invention relates to .beta.(1.fwdarw.6) glucosamine disaccharides having general formula (I) to a method for preparing these disaccharides, comprising the steps of: i) providing a starting material comprising lipid A moiety of lipopolysaccharide-comprising microorganisms; and ii) subjecting the starting material to an alkaline treatment such as lipid A moiety is O-deacylated at the 3-position and at the 3'-position, to pharmaceutical compositions comprising as an active ingredient these disaccharides, and to these disaccharides for use as an immunomodulating agent, anti-tumor agent, and vaccine component.
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