Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
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Dec 21, 1999
Grant Date -
N/A
app pub date -
Apr 11, 1995
filing date -
Apr 11, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides liver parenchymal cells having a clonal growth ability, which possesses at least one of the cell biological properties such as: presence of peroxysome; being positive to hepatocyte-markers; being partially positive to neoplastic hepatocyte-markers or immature hepatocyte-markers; being positive to antibodies against the surface antigens of ovall cells; and being partially positive to bile duct cell-markers. The present invention also provides a method for obtaining such cells and a method for subculturing such cells. With the liver parenchymal cells above, it will be possible to research in detail the process of development and differentiation, the mechanisms of growth and functional expression of hepatic cells, and to open up a new way to clalification of mechanisms or hepatoma and various other diseases and to development of therapeutic method against these disseases.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
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RESEARCH DEVELOPMENT CORPORATION OF JAPAN | CHIYODA-KU TOKYO 100 |
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Tateno, Chise | Hiroshima, JP | 1 | 7 |
# of filed Patents : 1 Total Citations : 7 | |||
Yoshizato, Katsutoshi | Hiroshima, JP | 25 | 387 |
# of filed Patents : 25 Total Citations : 387 |
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Patent Citation Ranking
- 7 Citation Count
- C12N Class
- 5.35 % this patent is cited more than
- 26 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
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Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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