Intracellular expression of carboxypeptidase G2 in a nitrogen mustard prodrug system
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United States of America Patent
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Dec 21, 1999
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Jan 30, 1997
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Jul 27, 1994
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Abstract
The invention provides a two component system for gene-directed enzyme prodrug therapy which comprises: (a) a vector which encodes a carboxypeptidase which is expressed within a cell; and (b) a prodrug which can be converted into an active drug by said carboxypeptidase, useful in the treatment of tumours.
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