Engraftment of immune-deficient mice with human cells
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United States of America Patent
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Nov 30, 1999
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app pub date -
Oct 17, 1994
filing date -
Sep 19, 1988
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Abstract
A process for transplanting into an immunodeficient mouse, which is deficient in T-cells and B-cells, human cells to form a chimeric mouse is provided. The transplanted human cells proliferate and thereby permit in vivo study of the human cells. The human cells are isolated from a human tissue source. The process comprises: i) irradiating an immunodeficient mouse deficient in T-cells and B-cells with radiation to condition the mouse for transplant: ii) transplanting into the irradiated mouse, the isolated human cells; and iii) maintaining the mouse to proliferate the human cells in and permit the human cells to spread in the mouse, to provide thereby a chimeric mouse incorporating the human cells in appropriate murine tissue.
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